Saturday, August 22, 2009

PLoS: estimates of respiratory failure from H1N1 in US

My foray onto knols -- just published one in PLoS Currents: Influenza that models the H1N1 epidemic in the US and estimates the number of acute respiratory failure cases that we can expect during the season. Pretty huge numbers! The table is reproduced here:

Table. Model input parameters and outcome estimates

Input Parameters

Estimate*

Source

US population

307,024,641

[6]

Estimated attack rate

15% (6%-24%)

[2]

Hospitalization rate, relative to attack rate

6% (2%-10%)

6% = CA experience, personal communication

2% = assumption

10% = [5]

ARF rate (relative to hospitalization)

12% (6%-18%)

12% = [5]

6% and 18% = assumption

Mortality rate (relative to ARF)

58% (40%-80%)

58% = [5]

40% and 80% =assumption

Outcomesò

Mean estimate

95% CI

Total cases

46,053,696

36,937,583-55,094,920

Number hospitalizations

2,763,222

2,034,413-3,585,032

ARF cases

331,587

227,866-454,001

Deaths

192,320

125,945-276,482

*Each input parameter was assumed to be normally distributed

òOutcome estimates and corresponding confidence intervals are based on Monte Carlo simulations, 10,000 trials for each outcome

CA = California, ARF = acute respiratory failure, CI = confidence interval

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